 FT | Cádiz  | 1 - 2 |  Girona | |
 FT | Beira-Mar  | 0 - 2 |  CF Os Belenenses | |
 FT | Sporting CP  | 2 - 2 |  Arouca | |
 FT | Mirassol  | 2 - 0 |  Botafogo | |
FT | Remo  | 1 - 2 |  Santos | |
 FT | San Jose Earthquakes  | 2 - 2 |  Los Angeles FC | |
FT | CF Montreal  | 0 - 2 |  Columbus Crew | |
FT | New England Revolution  | 4 - 2 |  Orlando City SC | |
FT | DC United  | 1 - 2 |  Charlotte | |
FT | Vasco DA Gama  | 5 - 0 |  Coritiba | |
FT | Sao Paulo  | 1 - 0 |  Internacional | |
FT | Minnesota United FC  | 2 - 3 |  Los Angeles Galaxy | |
FT | Houston Dynamo  | 2 - 2 |  FC Cincinnati | |
FT | Sporting Kansas City  | 3 - 4 |  Philadelphia Union | |
FT | FC Dallas  | 0 - 0 |  Austin | |
FT | St. Louis City  | 3 - 1 |  Toronto FC | |
 | Jeonbuk Motors  | vs |  Gwangju FC | |
| Gangwon FC  | vs |  Jeju United FC | |
 | Machida Zelvia  | vs |  Kashiwa Reysol | |
| Gamba Osaka  | vs |  Vissel Kobe | |
 | Dewa United  | vs |  PSS Sleman | |
| Pusamania Borneo  | vs |  Bali United | |
| Fafe  | vs |  Lajense | |
| Sacavenense  | vs |  Farense | |
 | Kudrivka  | vs |  Kolos Kovalivka | |
| Pohang Steelers  | vs |  FC Seoul | |
| Incheon United  | vs |  Daejeon Citizen | |
 | Hoàng Anh Gia Lai  | vs |  Hưng Yên | |
 | Piast Gliwice  | vs |  Pogon Szczecin | |
 | Feyenoord  | vs |  Utrecht |